The Yankees recalled the lefty on Saturday, according to the YES Network, to replace right-hander Ivan Nova, who left Friday's start with discomfort in his pitching elbow.
Nova, who exited in the third inning of Friday's 6-4 win over the Blue Jays, is expected to be placed on the 15-day disabled list. The results of an MRI on Nova's elbow were not released as of Friday night.
Nuno, 25, was 2-0 with a 1.54 ERA in four starts for Triple-A Scranton/Wilkes-Barre, striking out 26 in 23 1/3 innings.
Nuno was named the International League Pitcher of the Week for the week of April 15-21 and was also selected as James P. Dawson Award winner, which is the honor for the Yankees' best rookie in spring training.
After his senior season at Baker, Nuno was picked in the 48th round of the 2009 Major League Baseball Draft by the Cleveland Indians but was released in March 2011. He was picked up by the Yankees' organization three months later.
When pitching for the Wildcats in 2008 and 2009, he was a first-team all-conference selection twice and the Heart of America Athletic Conference Pitcher of the Year. Nuno was 15-7 with 15 complete games in his two years for the Wildcats.
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The Yankees will take on the Kansas City Royals at Kauffman stadium for a three-game set from May 10-12.