Baker fell to 14-11 overall and 7-8 in the HAAC, the Wildcats have now lost three straight.
Culver-Stockton hit 11 three-pointers in the first half and shot 40.7-percent from three, 11-of-27. The Wildcats entered halftime up 17 points, 44-27.
Four Wildcats scored in double figures for CSC, including 19 from point guard Marshawn Norris. Austin Keaton scored 17, James Johnson had 14 and Mario Gulley added 12.
Ben Steinlage and Kevin Lysaught each scored in double figures for Baker, as Steinlage dropped 12 and Lysaught scored 10.
Baker shot well from the free throw line, shooing 16-of-20 and Nick Wilson finished with a career high six points in just three minutes of action.
Each team took very good care of the ball with just seven turnovers apiece and CSC dominated the boards, outrebounding Baker, 44-34.
The Wildcats will travel to Olathe, Kan., this Thursday, Feb. 14 to take on rival No. 22 ranked MidAmerica Nazarene at 7:30 p.m.